AGRP polyclonal antibody; host Rabbit; reactivity Human, Rat, Mouse
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disease:Defects in AGRP may be a cause of autosomal dominant obesity [MIM:601665].,domain:The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.,function:Plays a role in weight homeostasis. May play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding.,similarity:Contains 1 agouti domain.,tissue specificity:Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.,
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | ELISA |
|---|---|---|
| Human,Rat,Mouse |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
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AGRP (agouti related neuropeptide; agouti-related protein) is a secreted neuropeptide that antagonizes melanocortin signaling, particularly at MC3R and MC4R. It is studied as a molecular regulator of hypothalamic feeding circuits and energy balance.
Biological function: Agouti-related protein antagonizes melanocortin-3 and melanocortin-4 receptor signaling. Curated NCBI evidence links AGRP to hypothalamic control of feeding behavior through melanocortin receptor and intracellular calcium regulation, supporting its established role in energy homeostasis.
