AFP polyclonal antibody; host Rabbit; reactivity Human, Rat, Mouse
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alpha fetoprotein(AFP) Homo sapiens This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | IHC-P | IF | ELISA |
|---|---|---|---|---|
| Human,Rat,Mouse |
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AFP (alpha fetoprotein; alpha-fetoprotein) encodes a major fetal plasma protein produced predominantly by the yolk sac and fetal liver. An albumin-family protein, AFP binds fatty acids, bilirubin and several metal ions and is widely studied in fetal development and liver biology.
Biological function: Alpha-fetoprotein (AFP) is a secreted fetal plasma protein structurally related to serum albumin. It binds fatty acids, bilirubin, copper and nickel and functions as a carrier protein during fetal life, with high production by the yolk sac and fetal liver before expression falls after birth.
