Recombinant Human CNTF Protein

Ciliary Neurotrophic Factor (CNTF) is a cytokine belonging to the Interleukin 6 (IL-6) family, which also includes IL-6, Oncostatin M, Leukemia Inhibitory Factor (LIF), and Cardiotrophin-1. Structurally, CNTF resembles a four-helix bundle composition, similar to the other members of the IL-6 family. The receptor for CNTF is composed of three parts: a gp130-like subunit common in the IL-6 receptor family, a LIF Receptor β subunit, and a CNTF specific α receptor subunit. Upon binding to the CNTF, the β subunit of the CNTF receptorwill undergo tyrosine phosphorylation, and activate the intracellular JAK/STAT pathway. The main function of CNTF in vivo is to promote the differentiation and survival of a variety of neurons and glial cells, including sympathetic precursor cells and spinal motor neurons. Recombinant human Ciliary Neurotrophic Factor (rhCNTF) produced in E. coli is a single non-glycosylated polypeptide chain containing 199 amino acids. A fully biologically active molecule, rhCNTF has a molecular mass of 22.8 kDa analyzed by reducing SDS-PAGE.

Product information

Supplier	Boster Bio
ABMIUM evidence status	ABMIUM Verified™ collaborator-tested data
Catalogue reference	R00609
Product category	Recombinant Proteins
Reactive species	Human
Gene name	CNTF
Protein name	Ciliary neurotrophic factor
Purification	>95%, by SDS-PAGE quantitative densitometry by Coomassie? Blue Staining.
Storage	Lyophilized recombinant human Ciliary Neurotrophic Factor (rhCNTF)remains stable up to 6 months at -80℃ from date of receipt. Upon reconstitution, rhCNTF remains stable up to 2 weeks at 4℃ or up to 3 months at -20℃.
UniProt	P26441
NCBI Gene ID	1270

Available variants

Conjugation	Size
Not applicable	100μg/vial