Rat TrkA ELISA Kit PicoKine®
ELISA Kit supplied by Boster Bio Read more ›
Product Description
Tropomyosin receptor kinase A (TrkA) are efficacious in attenuating skeletal pain.1 TrkA mutants were able to activate signaling cascades and were even more efficient in promoting neurite outgrowth than the wild-type receptor.2 TrkA is part of a sub-family of protein kinases which includes TrkB and TrkC. Also, there are other neurotrophic factors structurally related to NGF: BDNF (for Brain-Derived Neurotrophic Factor), NT-3 (for Neurotrophin-3) and NT-4 (for Neurotrophin-4). While TrkA mediates the effects of NGF, TrkB is bound and activated by BDNF, NT-4, and NT-3. Further, TrkC binds and is activated by NT-3.3 TrkA receptor was found in keratoconus-affected corneas, along with an increased level of repressor isoform of Sp3 transcription factor.4 The standard product used in this kit is extracellular part (A33-P418) of recombinant rat TRKA, consisting of 386 amino acids with the molecular weight of 69KDa.
Product information
| Supplier | Boster Bio |
|---|---|
| ABMIUM evidence status | ABMIUM Verified™ collaborator-tested data |
| Catalogue reference | EK0847 |
| Product category | PicoKine® ELISA Kits |
| Reactive species | Rat |
| Tested applications | ELISA |
| Gene name | NTRK1 |
| Protein name | High affinity nerve growth factor receptor |
| Sample type | cell culture supernatants and cell lysates. |
| Assay range | 78 pg/ml - 5,000 pg/ml |
| Sensitivity | <10 pg/ml |
| Specificity | Natural and recombinant rat TrkA |
| Immunogen | Expression system for standard: NS0; Immunogen sequence: A33-P418 |
| Storage | Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.) |
| UniProt | P35739 |
| NCBI Gene ID | 59109 |
Available variants
| Conjugation | Size |
|---|---|
| Not applicable | 96 wells/kit, with removable strips. |
Key Facts
| Target | High affinity nerve growth factor receptor |
| Also known as | neurotrophic receptor tyrosine kinase 1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; NTRK1 |
| Species reactivity | Rat |
| Purity | Natural and recombinant rat TrkA |
| Shelf life | Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.) |
| Sensitivity | <10 pg/ml |
| Detection range | 78 pg/ml - 5,000 pg/ml |
| Sample types |
cell culture supernatants and cell lysates.
See sample validation ›
|
Sample Type Validation
1 sample type| Sample Type | SERUM | PLASMA (EDTA) | URINE | CSF | CELL SUPERNATANT |
|---|---|---|---|---|---|
| cell culture supernatants and cell lysates. |
Specifications
Storage & Stability
Compliance & Certifications
Not intended for diagnostic or therapeutic use.