TACE (phospho Thr735) antibody from Promab.
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Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity. Cleaves the membrane-bound precursor of TNF to its mature soluble form. ADAM17 is responsible for the proteolytical release of soluble JAM3 from endothelial cells surface.
For research use only.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IHC-P | IHC-F | IF/ICC | Flow Cytometry | ELISA | IP | ChIP |
|---|---|---|---|---|---|---|---|---|---|
| Human | |||||||||
| Mouse | |||||||||
| Rat |
This product is manufactured by Promab and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
ADAM metallopeptidase domain 17 (ADAM17), widely known as TNF-alpha converting enzyme (TACE), is a membrane metalloprotease and ectodomain sheddase. This ABMIUM guide connects the verified target identity, catalogue-backed research products and authoritative NCBI/UniProt evidence.
Biological function: ADAM metallopeptidase domain 17 (ADAM17/TACE) is a transmembrane zinc metalloprotease that releases the extracellular domains of multiple membrane proteins. Reviewed UniProt includes cleavage of membrane-bound TNF precursor to soluble TNF and shedding of receptors and ligands including TNF receptors and IL6R.
