ABMIUM
Manufactured by:Promab
RUO

Anti-RNF135(C-term) Rabbit Polyclonal Antibody

RNF135(C-term) antibody from Promab.

SKU:
ABM416661-1
Product type
Primary antibodies
TargetRNF135(C-term)
ApplicationsWB
Species / reactivityHuman

Manufacturer provenance

Manufactured by:
Promab
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

Know who made it. See the evidence. Buy through one marketplace.

Product description

E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response. Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyses the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signalling pathway. Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signalling pathway.

For research use only.

Key facts & specifications
Also known as
E3 ubiquitin-protein ligase RNF135; 632-; RIG-I E3 ubiquitin ligase; REUL; RING finger protein 135; Riplet; RNF135; RNF135(C-term)
Host species
Rabbit
Clonality
Polyclonal
Conjugation
Unconjugated
Immunogen
This RNF135 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 375-401 amino acids from the C-terminal region of human RNF135.
Molecular weight
47.9 kDa
Validation & performance evidence
ABMIUM Validated™ ABMIUM Verified™ Expected performance Not suitable

Application matrix

Evidence status by application and model.

SpeciesWBIHCIHC-PIHC-FIF/ICCFlow CytometryELISAIPChIP
Human
Identifiers & database references
Gene symbol
RNF135
Gene ID
84282
UniProt accession
Q8IUD6
Ensembl
ENSG00000181481
HGNC
21158
OMIM
611358
Storage, stability & shipping
Short-term storage
4°C (short term)
Long-term storage
-20°C (long term); aliquot and avoid repeated freeze-thaw cycles
Storage buffer
Purified antibody in PBS with 0.05% sodium azide.
Aliquoting guidance
Aliquot to avoid repeated freeze-thaw.
Compliance & documents
CE marked
No
Frequently asked questions
Who manufactured this product?

This product is manufactured by Promab and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

Promab
£174.20