Osteocalcin (N-term) antibody from Promab.
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The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein. BGLAP acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. BGLAP binds strongly to apatite and calcium upon gamma-carboxylation; this modification is essential for bone metabolism.
For research use only.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IHC-P | IHC-F | IF/ICC | Flow Cytometry | ELISA | IP | ChIP |
|---|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Promab and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
BGLAP encodes bone gamma-carboxyglutamate protein, better known as osteocalcin (OC/BGP), a vitamin K-dependent osteoblast-secreted protein of mineralized bone matrix.
Biological function: Osteocalcin undergoes vitamin K-dependent gamma-carboxylation, enabling binding to calcium and hydroxyapatite. The carboxylated protein is a major non-collagenous component of bone matrix and contributes to bone formation and remodelling biology.
