Recombinant Mouse CD125/IL5RA Protein, N-His from ProteoGenix; catalogue ARO-P10601; research use only.
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Recombinant Mouse CD125/IL5RA Protein, also known as Interleukin 5 Receptor Alpha (IL5RA), is a protein that plays a crucial role in the immune system. It is a transmembrane protein that is expressed on the surface of various immune cells, including eosinophils, basophils, and mast cells. This protein is involved in the binding and signaling of Interleukin 5 (IL-5), a cytokine that regulates the growth and function of these immune cells. In this article, we will discuss the structure, activity, and applications of Recombinant Mouse CD125/IL5RA Protein.
Recombinant Mouse CD125/IL5RA Protein is a 60 kDa protein that is composed of 436 amino acids. It is a type I transmembrane protein, meaning that it has a single transmembrane domain that anchors it to the cell membrane. The extracellular domain of this protein contains several conserved cysteine residues that are important for its structural stability. The intracellular domain, on the other hand, is responsible for initiating downstream signaling upon ligand binding.
The main function of Recombinant Mouse CD125/IL5RA Protein is to bind to IL-5 and initiate downstream signaling. IL-5 is a cytokine that is produced by T helper 2 (Th2) cells and plays a critical role in the regulation of eosinophils, basophils, and mast cells. When IL-5 binds to Recombinant Mouse CD125/IL5RA Protein, it induces the dimerization of the receptor and activates the Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) signaling pathway. This leads to the activation of various transcription factors that regulate the growth, survival, and function of these immune cells.
Recombinant Mouse CD125/IL5RA Protein has a wide range of applications in both basic research and clinical settings. Here are some of its key applications:
Recombinant Mouse CD125/IL5RA Protein is a valuable tool for studying the IL-5 signaling pathway. By blocking the interaction between IL-5 and its receptor, researchers can investigate the specific role of this cytokine in various cellular processes. This can provide insights into the pathogenesis of diseases such as asthma, allergies, and parasitic infections, where IL-5 plays a crucial role.
Since IL-5 is involved in the regulation of eosinophils, basophils, and mast cells, it has been targeted for the treatment of diseases such as asthma and eosinophilic disorders. Recombinant Mouse CD125/IL5RA Protein can be used in high-throughput screening assays to identify potential therapeutic agents that can block the IL-5 signaling pathway. This can aid in the development of new treatments for these diseases.
Recombinant Mouse CD125/IL5RA Protein can also be used as an antigen to produce antibodies that specifically recognize this protein. These antibodies can then be used in various immunoassays, such as Western blotting, immunohistochemistry, and flow cytometry, to detect and quantify the expression of Recombinant Mouse CD125/IL5RA Protein in different cell types and tissues.
Abnormal levels of IL-5 and its receptor have been associated with various diseases, including asthma, allergies, and parasitic infections. Therefore, measuring the expression of Recombinant Mouse CD125/IL5RA Protein can serve as a biomarker for these diseases. This can
ProteoGenix catalogue number ARO-P10601. For research use only.
Host: Escherichia coli (E.coli); Expression system: Prokaryotic expression; Molecular weight: 36.14 kDa; Fragment: Asn32-Gly329; Buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol..
Available configurations: 50ug, 100ug, 1mg.
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
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Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
