Recombinant Human GSE1 Protein, N-His-SUMO & C-Strep from ProteoGenix; catalogue ARO-P11772; research use only.
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Recombinant proteins have become an indispensable tool in various fields of research, including biotechnology, medicine, and diagnostics. One such protein is the Recombinant Human GSE1 Protein, which has gained significant interest due to its unique structure, activity, and potential applications. In this article, we will delve into the details of this protein and explore its various aspects.
The Recombinant Human GSE1 Protein, also known as GTPase Stimulating Factor E1, is a 63 kDa protein consisting of 553 amino acids. It is encoded by the GSE1 gene located on human chromosome 22q13.2. The protein contains a conserved N-terminal domain, a central domain, and a C-terminal domain. The N-terminal domain is responsible for the interaction with other proteins, while the central domain contains a GTPase-activating protein (GAP) domain, which is essential for its activity.
The main function of the Recombinant Human GSE1 Protein is to regulate the activity of small GTPases, specifically the Rho family of GTPases. These GTPases are key players in various cellular processes, including cell growth, differentiation, and migration. The GAP domain of GSE1 binds to the active form of Rho GTPases and stimulates its GTPase activity, leading to the hydrolysis of GTP to GDP. This results in the inactivation of Rho GTPases, thereby regulating their downstream signaling pathways.
Moreover, studies have shown that Recombinant Human GSE1 Protein also has a role in the regulation of actin cytoskeleton dynamics. It has been reported that GSE1 interacts with actin-binding proteins, such as profilin and cofilin, and modulates their activities. This further highlights the crucial role of this protein in cell motility and cytoskeletal organization.
The unique structure and activity of Recombinant Human GSE1 Protein make it a promising candidate for various applications. One of the potential applications of this protein is in cancer research. It has been observed that GSE1 is overexpressed in various types of cancer, and its overexpression is associated with tumor growth and metastasis. Therefore, targeting GSE1 using recombinant protein inhibitors could have therapeutic potential in cancer treatment.
Furthermore, Recombinant Human GSE1 Protein has also been implicated in neurological disorders. Studies have shown that GSE1 is involved in neuronal development and synaptic plasticity. Mutations in the GSE1 gene have been linked to neurodevelopmental disorders, such as intellectual disability and autism spectrum disorders. Thus, recombinant GSE1 protein could be used as a tool to study the underlying mechanisms of these disorders and potentially develop targeted therapies.
In addition, the ability of Recombinant Human GSE1 Protein to regulate actin dynamics makes it a potential candidate in tissue engineering and regenerative medicine. It has been reported that GSE1 plays a role in the formation of new blood vessels, which is crucial for tissue repair and regeneration. Therefore, recombinant GSE1 protein could be used to enhance tissue regeneration and wound healing.
ConclusionIn conclusion, Recombinant Human GSE1 Protein is a multifaceted protein with a unique structure and activity. Its role in regulating small GTPases and actin dynamics makes it a promising candidate for various applications, including cancer treatment, neurological disorders, and tissue engineering. Further research on this protein could lead to a better understanding of its functions and potential therapeutic uses.
ProteoGenix catalogue number ARO-P11772. For research use only.
Host: Escherichia coli (E.coli); Expression system: Prokaryotic expression; Molecular weight: 22.45 kDa; Fragment: Gly754-Ser826; Buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol..
Available configurations: 50ug, 100ug, 1mg.
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