Recombinant Human AKAP8 Protein, N-GST from ProteoGenix; catalogue ARO-P10320; research use only.
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Recombinant Human AKAP8 Protein, also known as A-kinase anchor protein 8, is a key regulatory protein involved in various cellular processes. This protein is a member of the A-kinase anchor protein family and is encoded by the AKAP8 gene. It is expressed in a wide range of tissues and is essential for maintaining proper cellular function. In this article, we will discuss the structure, activity, and applications of Recombinant Human AKAP8 Protein.
Recombinant Human AKAP8 Protein is a large protein with a molecular weight of approximately 150 kDa. It is composed of 1521 amino acids and has a unique domain structure. The N-terminal region of the protein contains a highly conserved amphipathic helix, which is responsible for its interaction with other proteins. This region also contains a nuclear localization signal, indicating its role in nuclear localization.
The central region of Recombinant Human AKAP8 Protein contains multiple ankyrin repeats, which are known to mediate protein-protein interactions. These repeats are responsible for the binding of AKAP8 to various target proteins, including protein kinase A (PKA) and protein phosphatase 1 (PP1). The C-terminal region of the protein contains a leucine zipper motif, which is involved in dimerization and is essential for its function as an anchor protein.
Recombinant Human AKAP8 Protein is a multifunctional protein that plays a crucial role in regulating various cellular processes. One of its primary functions is to act as an anchor for PKA and PP1, two key enzymes involved in cellular signaling. This anchoring function allows for the spatial and temporal regulation of these enzymes, leading to precise control of their activity.
In addition to its role as an anchor protein, Recombinant Human AKAP8 Protein also has a role in chromatin remodeling. It interacts with histone deacetylases (HDACs) and histone acetyltransferases (HATs), which are involved in the modification of histones and regulation of gene expression. AKAP8’s interaction with these enzymes suggests its involvement in the regulation of gene expression and chromatin structure.
Furthermore, Recombinant Human AKAP8 Protein has been shown to play a role in DNA repair. It interacts with DNA damage response proteins and is essential for the recruitment of these proteins to sites of DNA damage. This function of AKAP8 is crucial for maintaining genomic stability and preventing the accumulation of mutations.
Due to its diverse functions, Recombinant Human AKAP8 Protein has a wide range of applications in both basic research and clinical settings. One of its primary applications is in the study of cellular signaling pathways. By acting as an anchor for PKA and PP1, AKAP8 allows for the precise regulation of these enzymes, making it an essential tool for understanding their role in cellular processes.
Furthermore, Recombinant Human AKAP8 Protein has been implicated in various diseases, including cancer and neurodegenerative disorders. Its involvement in chromatin remodeling and DNA repair suggests its potential as a therapeutic target for these diseases. Additionally, AKAP8’s interaction with HDACs and HATs makes it a potential target for epigenetic therapies.
Moreover, Recombinant Human AKAP8 Protein has been used in drug discovery and development. Its role in regulating cellular processes and its interaction with multiple target proteins make it a valuable tool for identifying and validating potential drug targets.
In summary, Recombinant Human AKAP8 Protein is a multifunctional protein with a unique domain structure. It plays a crucial role in regulating cellular signaling, chromatin remodeling, and DNA repair. Its
ProteoGenix catalogue number ARO-P10320. For research use only.
Host: Escherichia coli (E.coli); Expression system: Prokaryotic expression; Molecular weight: 91.06 kDa; Fragment: Met1-Glu572; Buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol..
Available configurations: 50ug, 100ug, 1mg.
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