Mouse PAD4 protein-arginine deiminase type-4 Recombinant Protein from ProteoGenix; catalogue PX-P4068; research use only.
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Mouse PAD4 (PADI4) functions as a transcriptional coregulator by catalyzing the conversion of histone H3 arginine residues to citrulline residues. This reaction, known as citrullination, leads to the post-translational modification of proteins.
PADI4 gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. PAD4 is mainly expressed in granulocytes, monocytes and CD34+ stem cells. Protein arginine deiminase type-4 was initially cloned from the HL-60 cell line (human promyelocytic leukemia cells). Protein arginine deiminase type-4 may play a role in granulocyte and macrophage development leading to inflammation and immune response. The PADI4 single-nucleotide polymorphism (SNP) and haplotypes were associated with rheumatoid arthritis susceptibility.
Recently, PAD4 has also been found in a variety of malignant tumors and implies its potential roles in tumor genesis.
Eukaryote expression systems and more specifically Insect cells are used at ProteoGenix to produce mouse PAD4 recombinant protein with appropriate post translational modifications.
ProteoGenix catalogue number PX-P4068. For research use only.
Host: Insect; Expression system: Eukaryotic expression; Purity: 90%; Molecular weight: 77.52kDa; Tag: Yes; Fragment: Full-length; Buffer: 50mM Tris-Cl pH 8.0, 150mM NaCl; Applications: ELISA, WB.
Available configurations: 50ug, 100ug, 1mg.
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
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Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
