Igovomab Biosimilar – Anti-MUC16 mAb – Research Grade from ProteoGenix; catalogue PX-TA1084; research use only.
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Igovomab is a biosimilar of the monoclonal antibody (mAb) anti-MUC16, which is a promising therapeutic target for various cancers. This research-grade antibody offers a potential treatment option for patients with MUC16-positive tumors. In this article, we will explore the structure, activity, and application of Igovomab in detail.
Igovomab is a recombinant humanized IgG1 antibody that specifically targets MUC16, also known as cancer antigen 125 (CA-125). It is composed of two heavy chains and two light chains, each containing a variable region and a constant region. The variable regions of the heavy and light chains are responsible for antigen binding, while the constant regions determine the antibody’s effector functions.
As an anti-MUC16 mAb, Igovomab binds to the extracellular domain of MUC16, which is overexpressed in various cancers, including ovarian, breast, lung, and pancreatic cancer. This binding inhibits the interaction of MUC16 with its cellular receptors, leading to the inhibition of tumor growth and metastasis. Igovomab also activates the immune system by inducing antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), further enhancing its anti-tumor activity.
Igovomab has shown promising results in preclinical studies and is currently being evaluated in clinical trials for the treatment of MUC16-positive tumors. In a phase I trial, Igovomab demonstrated a favorable safety profile and showed promising anti-tumor activity in patients with advanced ovarian cancer. It has also been evaluated in combination with other anti- cancer therapies, such as chemotherapy and immune checkpoint inhibitors, for potential synergistic effects.
The development of Igovomab as a biosimilar offers several potential benefits. Firstly, it provides an alternative treatment option for patients with MUC16-positive tumors. Secondly, it has the potential to reduce the cost of treatment, making it more accessible to patients. Additionally, biosimilars undergo a rigorous approval process, ensuring their safety and efficacy, providing healthcare professionals and patients with confidence in their use.
The development of biosimilars, including Igovomab, comes with its own set of challenges. One of the main challenges is the complexity of the manufacturing process, as even small changes in the production process can affect the final product. This requires strict quality control measures to ensure consistency and comparability to the reference product. Another challenge is the potential for immunogenicity, where the body may develop an immune response to the biosimilar, leading to reduced efficacy or adverse reactions.
In conclusion, Igovomab is a promising biosimilar of the anti-MUC16 mAb, offering a potential treatment option for patients with MUC16-positive tumors. Its unique structure and activity make it a promising therapeutic agent, with potential benefits in terms of efficacy, safety, and cost. However, the development of biosimilars, including Igovomab, comes with its own set of challenges, which need to be addressed to ensure the safe and effective use of these treatments. Further research and clinical trials are needed to fully understand the potential of Igovomab and its role in the treatment of MUC16-positive tumors.
ProteoGenix catalogue number PX-TA1084. For research use only.
Target: Igovomab Biosimilar – Anti-MUC16 mAb – Research Grade; Clonality: Monoclonal Antibody; Expression system: Mammalian cells; Purity: >85%; Buffer: PBS buffer PH7.5; Applications: ELISA, WB.
Available configurations: 50ug, 100ug, 1mg.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Target | WB | IHC-P | IHC-Fr | IF/ICC | Flow Cyt | IP | ChIP | ELISA |
|---|---|---|---|---|---|---|---|---|
| Igovomab Biosimilar – Anti-MUC16 mAb – Research Grade |
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
