Human FLT1 recombinant protein from ProteoGenix; catalogue PX-P6096; research use only.
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Human Fms-like tyrosine kinase 1 (FLT1) is a type I membrane receptor belonging to the vascular endothelial growth factor receptor (VEGFR) family. It is composed of an extracellular domain, a single transmembrane domain, and an intracellular domain. The extracellular domain of FLT1 binds to VEGF-A, VEGF-C, and VEGF-D, while the intracellular domain has tyrosine kinase activity. FLT1 is involved in the regulation of angiogenesis, vascular permeability, and cell proliferation.
FLT1 as an Antibody-Drug TargetFLT1 is an attractive target for antibody-drug conjugates (ADCs) due to its role in tumor growth and angiogenesis. ADCs are composed of an antibody linked to a cytotoxic drug. The antibody binds to the FLT1 receptor and the drug is internalized, leading to cell death. FLT1-targeted ADCs have been used in clinical trials for various types of cancer, including ovarian, gastric, and colorectal cancers.
ProteoGenix catalogue number PX-P6096. For research use only.
Host: Mammalian cells; Expression system: Eukaryotic expression; Purity: >85% by SDS-PAGE; Molecular weight: 37.77 kDa; Tag: C-Terminal His Tag; Fragment: Met1-Ile328; Buffer: 0.01M PBS, pH 7.4.; Applications: ELISA, WB.
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