IFN-γRα rabbit pAb from ELK Biotechnology Read more ›
IFN-γRα rabbit pAb is a research-use antibody from ELK Biotechnology for studying IFN-γRα in WB, IHC, IF, ELISA workflows with listed reactivity for Human, Mouse, Rat, Monkey. Specifications and supporting documents below should be reviewed when planning the experiment.
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008],
| Specificity | IFN-γRα Polyclonal Antibody detects endogenous levels of IFN-γRα protein. |
|---|---|
| Validation evidence captions | Immunofluorescence analysis of HepG2 cells, using Interferon-gamma Receptor alpha chain Antibody. The picture on the right is blocked with the synthesized peptide. | Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Interferon-gamma Receptor alpha chain Antibody. The picture on the right is blocked with the synthesized peptide. | Western blot analysis of lysates from COS7 cells, using Interferon-gamma Receptor alpha chain Antibody. The lane on the right is blocked with the synthesized peptide. |
| Collaborator | ELK Biotechnology |
| Partner model | ES5839 |
| Target | IFN-γRα |
| Research areas | >>Cytokine-cytokine receptor interaction, >>HIF-1 signaling pathway, >>Necroptosis, >>Osteoclast differentiation, >>JAK-STAT signaling pathway, >>Natural killer cell mediated cytotoxicity, >>Th1 and Th2 cell differentiation, >>Th17 cell differentiation, >>Leishmaniasis, >>Chagas disease, >>Toxoplasmosis, >>Tuberculosis, >>Influenza A, >>Kaposi sarcoma-associated herpesvirus infection, >>Herpes simplex virus 1 infection, >>Pathways in cancer, >>PD-L1 expression and PD-1 checkpoint pathway in cancer, >>Inflammatory bowel disease |
| Reactivity | Human,Mouse,Rat,Monkey |
| Applications | WB,IHC,IF,ELISA |
| Conjugation | Unconjugated |
| Dilution range | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Interferon-gamma Receptor alpha chain. AA range:431-480 |
| Concentration | 1 mg/ml |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Assay type | Antibody validation/application |
| Expression system | Blood,Liver,Prostate, |
| Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Mouse | |||||||
| Rat | |||||||
| Monkey |
| Species | Dilution | Notes |
|---|---|---|
| Human | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications. | — |
| Mouse | — | — |
| Rat | — | — |
| Monkey | — | — |
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Collaborator meets ABMIUM quality standards and overall product performance standards have been met.
Quality management certification.
For research applications. Not for diagnostic use.
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