Kininogen 1 Rabbit pAb
Kininogen 1 Rabbit pAb from ELK Biotechnology Read more ›
Product Description
Kininogen 1 Rabbit pAb is an ELK Biotechnology antibody for research workflows involving Kininogen 1.
Background
Kininogens are inhibitors of thiol proteases; HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects. LMW-kininogen inhibits the aggregation of thrombocytes; LMW-kininogen is in contrast to HMW-kininogen not involved in blood clottingUCHL1, UCHL3, UCHL5/UCH37, and BRCA-1-associated protein-1 (BAP1) belong to the UCH family of DUBs, which all posses a conserved catalytic domain (UCH domain) of about 230 amino acids. UCHL1 is abundantly expressed in neuronal tissues and testes.
Additional antibody information
| Validation evidence captions | Western blot analysis of 1) Human Serum, 2) Rat Kidney Tissue Lysate , 3) Mouse Kidney Tissue Lysate using （EA367）Rabbit pAb diluted at 1:1000. |
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Key Facts
| Target | Kininogen 1 |
| Also known as | BDK, Fitzgerald factor, HMWK, Ile Ser Bradykinin Bradykinin, Kallidin I Lysyl bradykinin, kininogen 1, KNG, KNG1 |
| Concentration | 1mg/mL |
| Working concentration | WB 1:1500-1,000 IHC 1:100-200 |
| Species reactivity | Human, Mouse, Rat |
| Observed band | 45-120kDa |
| Cellular localization | Secreted |
| Form / buffer | Antibody solution |
| Research area | Antibody Research |
| Host species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Tested applications |
WBIHC |
| Dilution range | WB 1:1500-1,000 IHC 1:100-200 |
| Immunogen | Recombinant Protein |
Reactivity & Application Validation
3 speciess| Species | WB | IHC | IF | ELISA | IP | FCM | CHIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Mouse | |||||||
| Rat |
| Species | Dilution | Notes |
|---|---|---|
| Human | WB 1:1500-1 | — |
| Mouse | — | — |
| Rat | — | — |
| Species | Dilution | Notes |
|---|
Specifications
Storage & Stability
Compliance & Certifications
Manufactured under ISO 9001:2015 quality management standards.
Not intended for diagnostic or therapeutic use.