Human Dieptidyl Peptidase 4, DPP-4 ELISA Kit
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Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed: 10951221, PubMed: 10900005, PubMed: 11772392, PubMed: 17287217). Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed: 10951221, PubMed: 10900005, PubMed: 11772392, PubMed: 14691230). Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed: 17287217). Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion (PubMed: 11772392). In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (PubMed: 16651416, PubMed: 10593948). May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation (PubMed: 18708048). When overexpressed, enhanced cell proliferation, a process inhibited by GPC3 (PubMed: 17549790). Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving Peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and Peptide hormones such as brain natriuretic Peptide 32 (PubMed: 16254193, PubMed: 10570924). Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (PubMed: 10593948). (Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | Serum | Plasma | Cell culture supernatants | Ascites | Tissue homogenates |
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
DPP4 identifies dipeptidyl peptidase 4 in Homo sapiens (Human). This target record connects NCBI Gene 1803, UniProtKB P27487 and related ABMIUM catalogue products.
Biological function: Dipeptidyl peptidase 4 (DPP4; CD26/DPP IV) is a type II transmembrane serine peptidase that removes N-terminal dipeptides from susceptible peptides and also functions as a cell-surface signalling and costimulatory protein. It is studied in incretin metabolism, glucose homeostasis and immune regulation.
