Human Angiotensin Converting Enzyme 2, ACE2 ELISA Kit
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Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed: 27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid Peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed: 10969042, PubMed: 10924499, PubMed: 11815627, PubMed: 19021774, PubMed: 14504186). Also removes the C-terminal residue from three other vasoactive Peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed: 10969042, PubMed: 11815627). Also cleaves other biological Peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed: 11815627, PubMed: 27217402, PubMed: 28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed: 18424768, PubMed: 19185582). [Isoform 2]: Non-functional as a carboxypeptidase. (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. [Isoform 2]: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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Angiotensin-converting enzyme 2 (ACE2; also known as ACEH) is a membrane-associated metallopeptidase in the renin-angiotensin system. This target record connects human NCBI Gene 59272, reviewed UniProtKB Q9BYF1 and related ABMIUM catalogue products.
Biological function: Angiotensin-converting enzyme 2 (ACE2) is a counter-regulatory carboxypeptidase of the renin-angiotensin system. It converts angiotensin I to angiotensin-(1-9) and angiotensin II to angiotensin-(1-7), helping counterbalance classical angiotensin II signalling and supporting cardiovascular homeostasis. ACE2 also functions as a cellular receptor for HCoV-NL63, SARS-CoV and SARS-CoV-2 spike proteins.
