Rat Disks Large Homolog 4, DLG4 ELISA Kit
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Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins (PubMed: 15317815, PubMed: 15358863, PubMed: 19596852, PubMed: 23300088, PubMed: 26679993). Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium Channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the Channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the Channels in an activated state in the presence of glutamate and preventing synaptic depression (PubMed: 19596852).
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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DLG4 identifies discs large MAGUK scaffold protein 4 in Homo sapiens (Human). This target record connects NCBI Gene 1742, UniProtKB P78352 and related ABMIUM catalogue products.
