ASS1 Monoclonal Antibody
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The protein encoded by this gene catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase. Mutations in the chromosome 9 copy of ASS cause citrullinemia. Two transcript variants encoding the same protein have been found for this gene.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Argininosuccinate synthase 1 (ASS1; argininosuccinate synthase) is a cytosolic urea-cycle enzyme that catalyzes ATP-dependent formation of argininosuccinate from citrulline and aspartate. This catalogue-backed ABMIUM record links human ASS1 (NCBI Gene 445; UniProt P00966) to research reagents.
Biological function: ASS1 catalyzes the ATP-dependent condensation of citrulline and aspartate to form argininosuccinate. This reaction is a core urea-cycle step and, together with argininosuccinate lyase, contributes to endogenous arginine biosynthesis.
