CD137 Monoclonal Antibody
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | WB | FCM | ELISA |
|---|---|---|---|
| Applications |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
TNF receptor superfamily member 9 (TNFRSF9), also known as 4-1BB or CD137, is an activation-induced costimulatory receptor in immune-cell signalling. ABMIUM catalogue products linked below support research on TNFRSF9/CD137 biology.
Biological function: TNF receptor superfamily member 9 (TNFRSF9/CD137/4-1BB) is a member of the TNF receptor superfamily. Following lymphocyte activation, TNFRSF9 signalling can support T-cell clonal expansion, survival and differentiation and engages TRAF-dependent pathways including NF-kappaB. Its activation-linked expression and costimulatory role make CD137/4-1BB widely studied in T-cell and immune-regulation research.
