Ref-1 (Acetyl Lys6) Polyclonal Antibody
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Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. APEX1 encodes the major AP endonuclease in human cells. Splice variants have been found for APEX1; all encode the same protein.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1; APE1/Ref-1) is the major human AP endonuclease and a multifunctional DNA-repair and redox regulator. It repairs abasic sites in base-excision repair and helps regulate redox-sensitive transcription-factor activity.
Biological function: APEX1 cleaves the DNA phosphodiester backbone immediately 5′ to apurinic/apyrimidinic sites generated spontaneously or during base-excision repair, creating DNA ends for downstream repair. Reviewed UniProt also supports a redox-regulatory role toward transcription factors, linking genome maintenance with oxidative-stress signalling.
