BMP-7 Polyclonal Antibody
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BMP7 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Bone morphogenetic protein 7 (BMP7/BMP-7), also known as osteogenic protein 1 (OP-1), is a secreted TGF-beta-superfamily growth factor involved in skeletal, renal and developmental signalling. ABMIUM catalogue products linked below support research on BMP7 biology.
Biological function: BMP7 initiates canonical BMP signalling through receptor complexes including ACVR1 and ACVR2A, activating SMAD1/5/8-dependent transcription. Reviewed UniProt supports roles in embryogenesis, skeletal morphogenesis, neurogenesis and hematopoiesis, with additional context in kidney biology and HAMP regulation.
