APLP-1 Polyclonal Antibody
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APLP1 encodes a member of the highly conserved amyloid precursor protein gene family. The amyloid-like protein 1 is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
APLP1 (amyloid beta precursor like protein 1; APLP) is a neuronal membrane glycoprotein in the amyloid precursor protein family. It undergoes secretase-dependent processing and is studied in synaptic maturation, neuronal signalling and APP-family biology.
Biological function: APLP1 is processed by secretases in a manner related to other amyloid precursor protein family members. Reviewed UniProt supports roles in postsynaptic function, signalling through C-terminal binding partners and regulation of neurite outgrowth through extracellular-matrix interactions.
