ABMIUM target intelligence
activin A receptor type 2A
Activin A receptor type 2A (ACVR2A) encodes activin receptor type-2A, a transmembrane serine/threonine kinase receptor of the TGF-beta superfamily signalling system. Human ACVR2A maps to NCBI Gene 92 and reviewed UniProtKB P27037; this record links the verified target to related ABMIUM catalogue products.
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Research context & evidence
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ACVR2A is a type II activin receptor with an extracellular ligand-binding domain and intracellular serine/threonine kinase domain. After ligand binding it forms receptor complexes with type I receptors; the type II receptor phosphorylates and activates type I receptors, which then propagate signalling through SMAD transcriptional regulators. Reviewed UniProt identifies activin A, activin B and inhibin A among its ligands.
ACVR2A, also called activin receptor type-2A or ActRIIA, is studied in activin/TGF-beta-family signalling, receptor-complex assembly, SMAD pathway regulation, development and cell-state responses. Select related ABMIUM research products only after confirming species, sample type, assay/application and product-level validation.
Names used across publications, databases and supplier catalogues.
