Bim polyclonal antibody; host Rabbit; reactivity Human, Mouse, Rat, Monkey
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BCL2 like 11(BCL2L11) Homo sapiens The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | IHC-P | IF | ELISA |
|---|---|---|---|---|
| Human,Mouse,Rat,Monkey |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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BCL2L11 (BCL2 like 11), commonly called BIM or Bcl-2-like protein 11, is a BH3-only BCL-2-family regulator that helps initiate mitochondrial apoptosis in response to developmental and cellular stress signals.
Biological function: BCL2L11 encodes a BH3-only pro-apoptotic BCL-2-family protein. BIM engages anti-apoptotic BCL-2-family members and helps shift mitochondrial signalling toward activation of the intrinsic apoptosis machinery. Alternative splicing generates multiple BCL2L11 isoforms whose abundance and activity are regulated by cell state and signalling inputs.
