ABMIUM target intelligence
BCL2 like 11
BCL2L11 (BCL2 like 11), commonly called BIM or Bcl-2-like protein 11, is a BH3-only BCL-2-family regulator that helps initiate mitochondrial apoptosis in response to developmental and cellular stress signals.
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Research context & evidence
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BCL2L11 encodes a BH3-only pro-apoptotic BCL-2-family protein. BIM engages anti-apoptotic BCL-2-family members and helps shift mitochondrial signalling toward activation of the intrinsic apoptosis machinery. Alternative splicing generates multiple BCL2L11 isoforms whose abundance and activity are regulated by cell state and signalling inputs.
BCL2L11/BIM is studied in intrinsic apoptosis, growth-factor withdrawal, lymphocyte and neuronal cell-death programmes, and stress-response signalling. Experimental work often examines BIM expression, isoform usage and phosphorylation-dependent regulation alongside other BCL-2-family proteins.
Names used across publications, databases and supplier catalogues.
