Kit ELISA fourni par Boster Bio
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Le GDF-15 (facteur de différenciation de croissance 15), également connu sous les noms de TGF-PL, MIC-1, PLAB et PTGFB, est une protéine appartenant à la superfamille des facteurs de croissance transformants bêta qui joue un rôle dans la régulation des voies inflammatoires et apoptotiques dans les tissus lésés et pendant les processus pathologiques. Son expression hépatique peut être significativement régulée à la hausse lors de lésions d'organes tels que le foie, les reins, le cœur et les poumons. Le GDF15 a montré une expression et une sécrétion accrues pendant la maturation des érythroblastes. Le GDF15 fonctionne comme une cytokine anti-inflammatoire en interférant avec la signalisation des chimiokines et l'activation des intégrines.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Compatibilité de l'échantillon | Gamme de test | Sensibilité | Spécificité |
|---|---|---|---|---|
| surnageants de culture cellulaire | ||||
| lysats cellulaires | ||||
| sérum et plasma (héparine | ||||
| EDTA). |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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GDF15 identifies growth differentiation factor 15 in Homo sapiens (Human). This target record connects NCBI Gene 9518, UniProtKB Q99988 and related ABMIUM catalogue products.
Biological function: GDF15 is a secreted stress-responsive hormone/cytokine that communicates physiological stress to the brain. It binds GFRAL and forms a signalling complex with RET in brainstem neurons, producing responses that include reduced food intake and altered energy balance; circulating GDF15 is also widely studied in metabolic stress, pregnancy, cancer and cachexia.
