ABMIUM target intelligence
growth differentiation factor 15
GDF15 identifies growth differentiation factor 15 in Homo sapiens (Human). This target record connects NCBI Gene 9518, UniProtKB Q99988 and related ABMIUM catalogue products.
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Research context & evidence
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GDF15 is a secreted stress-responsive hormone/cytokine that communicates physiological stress to the brain. It binds GFRAL and forms a signalling complex with RET in brainstem neurons, producing responses that include reduced food intake and altered energy balance; circulating GDF15 is also widely studied in metabolic stress, pregnancy, cancer and cachexia.
GDF15 is studied across metabolic disease, obesity and weight regulation, cellular stress, inflammation, oncology, treatment-associated nausea/cachexia and pregnancy biology. Its highly context-dependent expression makes it useful for mechanistic and biomarker research, but changes in abundance should be interpreted alongside tissue, disease state and experimental model rather than as a stand-alone indicator.
Names used across publications, databases and supplier catalogues.
