CD279 Recombinant Protein from ProteoGenix; catalogue PX-P4117; research use only.
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CD279 (programmed cell death protein 1; PD-1) is a type I transmembrane protein that belongs to the CD28 / CTLA-4 family of immune receptors, which mediates signals that regulate immune responses. Members of the CD28 / CTLA-4 family have been shown to promote T cell activation (CD28 and ICOS) or deactivate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, bone marrow cells, and some thymocytes. In vitro, CD279 binding can prevent TCR-mediated T cell proliferation and the production of IL-1, IL-4, IL-10, and IFN-γ. Furthermore, the binding of CD279 can also prevent BCR signaling. CD279-deficient mice have defective peripheral tolerance and spontaneously develop autoimmune diseases.
ProteoGenix catalogue number PX-P4117. For research use only.
Host: Mammalian cells; Expression system: Eukaryotic expression; Purity: >90% by SDS-PAGE; Molecular weight: 40kDa; Tag: C-terminal His Tag; Fragment: Met1~Val170; Buffer: PBS pH7.5; Applications: ELISA, WB.
Available configurations: 50ug, 100ug, 1mg.
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
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Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
