CD132 Recombinant Protein

General information on CD132 Recombinant Protein:

The common gamma chain (γc) (or CD132), also known as the interleukin 2 receptor γ or IL2RG subunit, is a member of the type I cytokine family and is expressed in most lymphocytes (leukocytes) and its cells in mammals. A gene was found on its X chromosome. The common γ (γc) chain (or IL2RG) is the cytokine receptor subunit, which is the cytokine receptor subunit shared by the receptor complexes of at least six different interleukin receptors. IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin 21 receptors. It is a component of many cytokine receptors, which are essential for the development and function of lymphocytes. Severe X-linked combined immunodeficiency (XSCID) is a rare and life-threatening disease caused by mutations in IL2RG (the gene that encodes IL2RG). Based on chemical binding data, IL2RG has been shown to be a component of the IL-4 receptor, that is, the ability of IL2RG to increase IL-4 binding affinity. The observation that the IL-2R range is a functional part of the IL-4 receptor, and the discovery that IL-2Rγ is related to the IL-7 receptor, began to explain why the lack of this γ chain common (γc) has an impact on lymphatic development and function. It has a profound impact, as seen in X-linked severe combined immunodeficiency.

ProteoGenix catalogue number PX-P4105. For research use only.

Host: Mammalian cells; Expression system: Eukaryotic expression; Purity: >90% by SDS-PAGE; Molecular weight: 30.70kDa; Tag: C-terminal His Tag; Fragment: Met1-Asn254; Buffer: PBS pH7.5; Applications: ELISA, WB.

Available configurations: 50ug, 100ug, 1mg.

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