Kit ELISA fourni par Boster Bio
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Le composant 3 du complément, souvent simplement appelé C3, est une protéine du système immunitaire. Chez l'homme, il est codé sur le chromosome 19 par un gène appelé C3. Le composant C3 du complément joue un rôle central dans l'activation du système du complément. Son activation est nécessaire aux voies d'activation du complément classique et alternative. La préproprotéine codée est traitée par protéolyse pour générer des sous-unités alpha et bêta qui forment la protéine mature, qui est ensuite traitée pour générer de nombreux produits peptidiques. Le peptide C3a, également connu sous le nom d'anaphylatoxine C3a, module l'inflammation et possède une activité antimicrobienne. Les mutations de ce gène sont associées au syndrome hémolytique et urémique atypique et à la dégénérescence maculaire liée à l'âge chez les patients humains.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Compatibilité de l'échantillon | Gamme de test | Sensibilité | Spécificité |
|---|---|---|---|---|
| surnageants de cultures cellulaires | ||||
| sérum | ||||
| plasma (héparine | ||||
| EDTA | ||||
| citrate) et urine |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
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C3 (complement C3) is the central complement precursor cleaved into C3a and C3b, linking complement activation to inflammatory signalling, opsonization and downstream C5 activation.
Biological function: Complement C3 is activated by C3 convertases across the classical, lectin and alternative pathways. Cleavage generates C3a, an anaphylatoxin involved in inflammatory signalling, and C3b, which covalently labels surfaces for opsonization, supports complement amplification and contributes to C5 convertase formation. Additional processing generates iC3b and other fragments with distinct immune functions.
