Kit ELISA fourni par Boster Bio
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L'anhydrase carbonique 12 est une enzyme qui, chez l'homme, est codée par le gène CA12. Elle est localisée sur 15q22.2. Les anhydrases carboniques (AC) sont une grande famille de métalloprotéines à zinc qui catalysent l'hydratation réversible du dioxyde de carbone. Elles participent à une variété de processus biologiques, y compris la respiration, la calcification, l'équilibre acido-basique, la résorption osseuse, et la formation de l'humeur aqueuse, du liquide céphalo-rachidien, de la salive et de l'acide gastrique. Ce produit génique est une protéine membranaire de type I fortement exprimée dans les tissus normaux, tels que le rein, le côlon et le pancréas, et a été trouvée surexprimée dans 10 % des carcinomes rénaux à cellules claires. Trois variants de transcription codant différentes isoformes ont été identifiés pour ce gène.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Compatibilité de l'échantillon | Gamme de test | Sensibilité | Spécificité |
|---|---|---|---|---|
| surnageants de culture cellulaire | ||||
| lysats cellulaires | ||||
| sérum et plasma (héparine | ||||
| EDTA | ||||
| citrate). |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Carbonic anhydrase 12 (CA12; carbonic anhydrase XII/CA-XII) is a type I transmembrane zinc metalloenzyme with an extracellular catalytic domain. It is studied in epithelial CO2/bicarbonate handling, extracellular pH regulation and tissue-specific membrane carbonic-anhydrase biology.
Biological function: CA12 catalyses reversible hydration of carbon dioxide at the cell surface, generating bicarbonate and protons and contributing to extracellular acid-base handling. Its transmembrane localisation links carbonic-anhydrase catalysis to epithelial transport and pH-regulatory systems.
