Anticorps polyclonal anti-ATG3 de lapin d'ELK Biotechnology
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L'anticorps polyclonal de lapin ATG3 est un anticorps d'ELK Biotechnology pour les flux de travail de recherche impliquant ATG3.
Ce gène code une enzyme de conjugaison de type ubiquitine et est un composant des systèmes de type ubiquitination impliqués dans l'autophagie, le processus de dégradation, de renouvellement et de recyclage des constituants cytoplasmiques dans les cellules eucaryotes. Cette protéine est connue pour jouer un rôle dans la régulation de l'autophagie pendant la mort cellulaire. Un pseudogène de ce gène est situé sur le chromosome 20. L'épissage alternatif donne lieu à de multiples variants de transcrits codant différentes isoformes. [fourni par RefSeq, juillet 2013],
| Spécificité | Cet anticorps détecte les niveaux endogènes d'ATG3 chez l'homme/la souris/le rat |
|---|---|
| Légendes des preuves de validation | Analyse par Western blot de lysats de cellules HEK293, l'anticorps primaire a été dilué à 1:1000, 4° pendant la nuit |
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Humain | |||||||
| Souris | |||||||
| Rat |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
ATG3 encodes an E2-like conjugating enzyme required for lipidation of ATG8-family proteins during autophagosome formation. This target record connects reviewed human ATG3 identifiers with ABMIUM catalogue products targeting ATG3.
Biological function: ATG3 is an E2 conjugating enzyme in the autophagy machinery. It catalyses covalent conjugation of ATG8-family proteins, including LC3 and GABARAP family members, to phosphatidylethanolamine-containing membrane lipids. ATG3 cycles between ATG7-mediated loading and the ATG12-ATG5-ATG16L1 E3-like complex to promote ATG8 lipidation and formation of autophagic isolation membranes.
