Recombinant Rhesus Macaque Eotaxin/CCL11 protein

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Recombinant Rhesus Macaque Eotaxin/CCL11 protein

Recombinant Rhesus Macaque Eotaxin/CCL11 protein

SKU:
ABM219022
Manufacturer SKU
CD00049
Product type
Recombinant Proteins
TargetRecombinant Rhesus Macaque Eotaxin/CCL11 protein
Expression systemEscherichia coli.
Purity> 98 % by SDS-PAGE and HPLC analyses.

Manufacturer provenance

Manufactured by:
BT LAB
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

Background

Rhesus Macaque CCL11 is belonging to the CC chemokine family. It is encoded by the gene CCL11. CCL11 was first purified from bronchoalveolar lavage fluid of guinea pigs. It was a strong and specific eosinophil chemoattractant in vitro. It can directly chemotactic for eosinophils, but not for monocytes or neutrophils. Rhesus macaque CCL11 is approximately 90 % identical at the amino acid level to human CCL11. In addition, CCL11 also shows about 60 % amino acid sequence identity to monkey MCP-1. CCR3 has been identified to be a specific CCL11 receptor.

Expression system
Escherichia coli.
Purity
> 98 % by SDS-PAGE and HPLC analyses.
Molecular weight
Approximately 8.4 kDa, a single non-glycosylated polypeptide chain containing 74 amino acids.
Endotoxin
Less than 0.1 EU/μg of rRhEotaxin/CCL11 as determined by LAL method.
Form
Sterile Filtered White lyophilized (freeze-dried) powder. Formulation Lyophilized from a 0.2 μm filtered concentrated solution in 2 × PBS, pH 6.9.

Packaging image shown for reference. Select a size from the available options.

Key facts & specifications
Research areas
Immunology
Also known as
Eotaxin/CCL11,Eotaxin, SCYA11, Monkey
Source organism
Rhesus
Molecular weight
Approximately 8.4 kDa, a single non-glycosylated polypeptide chain containing 74 amino acids.
Form / buffer
Sterile Filtered White lyophilized (freeze-dried) powder. Formulation Lyophilized from a 0.2 μm filtered concentrated solution in 2 × PBS, pH 6.9.
Activity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration range of 0.1-10.0 ng/ml.
Endotoxin level
Less than 0.1 EU/μg of rRhEotaxin/CCL11 as determined by LAL method.
Sequence
GPDSVATTCC FTLTNKKIPL QRLESYRRII SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDRKSP TPKP
Quantity per pack
5 ug
Technical note
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 C. Further dilutions should be made in appropriate buffered solutions.
Validation & performance evidence
ABMIUM Validated™ ABMIUM Verified™ Expected performance Not suitable

Application validation matrix

Evidence status by application and model.

EvidenceSDS-PAGEHPLCLALBioactivity
Quality control
Identifiers & database references
Manufacturer SKU
CD00049
UniProt accession
Q8MIT7
Storage, stability & shipping
Storage conditions
-20ºC
Storage buffer
Lyophilized from a 0.2 μm filtered concentrated solution in 2 × PBS, pH 6.9.
Compliance & documents
Datasheet
Open datasheet
Product manual
Open manual
Frequently asked questions
Who manufactured this product?

This product is manufactured by BT LAB and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

BT LAB
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