Mouse Autophagy Related Protein 4A, ATG4A ELISA Kit
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Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity).
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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ATG4A (autophagy related 4A cysteine peptidase), also called cysteine protease ATG4A or autophagin-2, is an ATG4-family cysteine protease that regulates ATG8-family protein processing during macroautophagy.
Biological function: ATG4A is a peptidase family C54 cysteine protease involved in the proteolytic processing of ATG8-family proteins. ATG4-family enzymes expose the C-terminal glycine needed for ATG8 lipidation and can reverse lipidation, helping regulate autophagosome membrane dynamics and autophagic flux.
