Mouse Junctional Adhesion Molecule C, JAM3 ELISA Kit
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Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed: 15372036, PubMed: 16093349). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed: 24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (PubMed: 16297198). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (PubMed: 15372036, PubMed: 15994945). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed: 16093349). Plays a role in angiogenesis (PubMed: 15994945). Plays a role in the regulation of cell migration (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). [Soluble form of JAM-C]: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | Serum | Plasma | Cell culture supernatants | Ascites | Tissue homogenates |
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| Compatibility |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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JAM3 identifies junctional adhesion molecule 3 in Homo sapiens (Human). This target record connects NCBI Gene 83700, UniProtKB Q9BX67 and related ABMIUM catalogue products.
