Rat Argininosuccinate Synthase, ASS1 ELISA Kit
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One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure (PubMed: 19491403).
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | Serum | Plasma | Cell culture supernatants | Ascites | Tissue homogenates |
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| Compatibility |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Argininosuccinate synthase 1 (ASS1; argininosuccinate synthase) is a cytosolic urea-cycle enzyme that catalyzes ATP-dependent formation of argininosuccinate from citrulline and aspartate. This catalogue-backed ABMIUM record links human ASS1 (NCBI Gene 445; UniProt P00966) to research reagents.
Biological function: ASS1 catalyzes the ATP-dependent condensation of citrulline and aspartate to form argininosuccinate. This reaction is a core urea-cycle step and, together with argininosuccinate lyase, contributes to endogenous arginine biosynthesis.
