Human Carbonic Anhydrase 2, CA-2 ELISA Kit
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Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled Peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | Serum | Plasma | Cell culture supernatants | Ascites | Tissue homogenates |
|---|---|---|---|---|---|
| Compatibility |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Carbonic anhydrase 2 (CA2; carbonic anhydrase II/CA-II, also CAC) is a highly active cytosolic zinc metalloenzyme that reversibly hydrates carbon dioxide. Researchers study CA2 in bicarbonate handling, intracellular pH control, renal physiology, bone biology and carbonic-anhydrase enzymology.
Biological function: CA2 catalyses the reversible interconversion of carbon dioxide and water with bicarbonate and protons. Its high catalytic efficiency supports rapid CO2/bicarbonate equilibration and acid-base homeostasis, and CA2 can participate in membrane-associated bicarbonate-transport complexes despite being primarily cytosolic.
