Human Plasminogen Activator Inhibitor 1, PAI-1 ELISA Kit
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Serine protease inhibitor. Inhibits TMPRSS7 (PubMed: 15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed: 8481516, PubMed: 9207454, PubMed: 17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed: 9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed: 15001579, PubMed: 9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed: 18386027). It is involved in cellular and replicative senescence (PubMed: 16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed: 25808697, PubMed: 27046084).
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | Serum | Plasma | Cell culture supernatants | Ascites | Tissue homogenates |
|---|---|---|---|---|---|
| Compatibility |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Serpin family E member 1 (SERPINE1), commonly called plasminogen activator inhibitor 1 (PAI-1), is a serine-protease inhibitor. This ABMIUM record links human SERPINE1 (NCBI Gene 5054; UniProt P05121) to catalogue-backed research products.
Biological function: SERPINE1/PAI-1 is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), making it an important inhibitor of fibrinolysis. Curated records also describe a role in innate antiviral immunity.
