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ionSIGHTDas Gesamtbild sehen

Eine KI-gesteuerte native Massenspektrometrie-Plattform, die direkte, hochpräzise Einblicke in die Proteinstruktur und Arzneimittelwechselwirkungen liefert.

Über ionSIGHT

ionSIGHT ist eine Ausgründung der Universität Oxford.

Tiefgreifende Fachkenntnisse in nativer Massenspektrometrie, maschinellem Lernen und spezialisierter Glykoproteinanalyse.

Die Plattform hilft Forschenden, über indirekte Ablesungen hinauszugehen, indem sie direkten Einblick in Proteinstruktur, Interaktionsverhalten und funktionelle Integrität liefert.

Native-Massenspektrometrie-Analyse
nMS
Native mass spec
AI
ML-driven analysis
Mass Spec QC

Mass Spec QC for Expressed Proteins to Complex Biologics

A structured quality ladder that moves from identity confirmation to covalent structure review and functional native MS evidence.

Core QC 1

Confirm protein identity

Bottom-up proteomic analysis confirms protein identity but sacrifices higher-order structural information.

Best fit when the main question is whether the expected protein is present.
Advanced QC 3

Preserve covalent structure

Top-down intact mass analysis preserves covalent structure enabling characterization of proteoforms, isoforms, and post-translational modifications (PTMs).

Best fit when accurate mass, purity, truncations, isoforms, and PTMs need review.
Premium QC 5

Preserve function

Native mass spectrometry preserves non-covalent interactions and higher-order structure, enabling assessment of conformational integrity, ligand binding, protein-protein interactions, and other functional attributes, in addition to covalent structure, isoforms, and PTMs.

Best fit when functional integrity, complex formation, and conformational state are critical quality attributes.

Core QC sample requirements

Nanogram to picogram quantities of pure protein in solution or gel bands excised from Coomassie-stained SDS PAGE gels.

Core QC outputs

Protein identities as Mascot protein database search results including hit ranking, MOWSE statistical score and peptide MSMS coverage.

Advanced QC sample requirements

A few micrograms of pure protein in solution at approximately 1 mg per ml.

Advanced QC outputs

Annotated intact protein mass spectra indicating protein identity by accurate mass, purity, truncations, isoforms and post-translational modifications (if present) including relative quantitation.

Premium QC sample requirements

Typically 50 micrograms of pure protein in solution in a total volume of 75 ul. Fresh or snap-frozen and supplied on dry ice.

Premium QC outputs

Annotated native protein mass spectra as advanced QC but including stoichiometry, ligand binding, ligand identity, binding affinity, stable conformers, percent activity, hydrodynamic radius and thermal stability.

Choosing the right Mass Spec QC for your protein

  • Protein QC should be appropriate for the protein’s intended use and the time, effort and cost this entails.
  • While both Core QC and Advanced QC provide essential molecular characterization, they may not distinguish between proteins that are structurally intact and functionally active versus covalently intact and functionally impaired. Native MS uniquely enables direct interrogation of higher-order assembly states and interaction profiles associated with biological function.
  • For this reason, we recommend Premium QC for any expressed protein where functional integrity, complex formation, and conformational state are critical quality attributes.
ABMIUM Partnerschaft

Strukturelle Einsicht am Point of Purchase

ionSIGHT und ABMIUM teilen ein gemeinsames Prinzip: Forscher verdienen bessere Daten, bevor sie Ressourcen einsetzen. Durch diese Partnerschaft informiert die native MS-Analyse von ionSIGHT den Proteinkarakterisierungskontext hinter den Produktlisten von ABMIUM.

Für Biotechnologie- und Pharma-Teams, die Reagenzien und Biologika über ABMIUM beziehen, stellt ionSIGHT eine zusätzliche Schicht unabhängiger wissenschaftlicher Genauigkeit von einem der qualifiziertesten Strukturbiologieteams in Europa dar.

ABMIUM ValidatedTM standards: this service adds an independent native mass spectrometry evidence layer to support validation confidence, reagent selection, and structured technical review.
ionSIGHT adheres to responsible research standards consistent with the ABMIUM sustainability framework.
ABMIUM Validation Partner

Was die ionSIGHT-Partnerschaft zu ABMIUM beiträgt

Native-MS-Daten liefern eine Dimension struktureller Wahrheit, die Bildgebungs- und biochemische Assays allein nicht erfassen können.

  • Protein structure and interaction data at the product listing level
  • Independent native MS validation conducted by Oxford-trained structural biologists
  • Direct binding confirmation not inferred from proxy assays
  • Stoichiometry and selectivity
Get in touch

Besprechen Sie eine Anforderung an die Proteinqualiätskontrolle oder -validierung.

Bitte teilen Sie uns den wissenschaftlichen Kontext, den Probentyp und die Entscheidung mit, die Sie mit den Daten untermauern möchten. Das Team wird die Anfrage prüfen und per E-Mail antworten.

Wissenschaftler, der Massenspektrometrie-Daten überprüft

Die Anfrage leichter bearbeitbar machen

Erzählen Sie uns, was Sie über Ihr Protein wissen

  • Core QC for protein identity questions
  • Advanced QC for intact mass and proteoform review
  • Premium QC for function-critical expressed proteins

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Das Gesamtbild mit ionSIGHT sehen

Native Massenspektrometrie in großem Maßstab. KI-gesteuerte Analyse. Direkte Beobachtung von Protein-Wirkstoff-Interaktionen durch eines der renommiertesten Strukturbiologie-Teams Europas.