ABMIUM target intelligence
ADAM metallopeptidase domain 17
ADAM metallopeptidase domain 17 (ADAM17), widely known as TNF-alpha converting enzyme (TACE), is a membrane metalloprotease and ectodomain sheddase. This ABMIUM guide connects the verified target identity, catalogue-backed research products and authoritative NCBI/UniProt evidence.
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Names used across publications, databases and supplier catalogues.
ADAM metallopeptidase domain 17 (ADAM17/TACE) is a transmembrane zinc metalloprotease that releases the extracellular domains of multiple membrane proteins. Reviewed UniProt includes cleavage of membrane-bound TNF precursor to soluble TNF and shedding of receptors and ligands including TNF receptors and IL6R.
ADAM17/TACE is widely studied in inflammatory signalling, cytokine and receptor shedding, TNF biology, IL6R trans-signalling, growth-factor signalling and cell-surface proteolysis. Reagent selection should be based on species, sample type, assay format, application and product-level validation.