ABMIUM target intelligence
low density lipoprotein receptor
LDLR identifies low density lipoprotein receptor in Homo sapiens (Human). This target record connects NCBI Gene 3949, UniProtKB P01130 and related ABMIUM catalogue products.
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Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
LDLR is a cell-surface receptor that binds LDL and related apolipoprotein-containing particles and internalizes them through clathrin-mediated endocytosis. This pathway is central to cellular cholesterol uptake and plasma LDL clearance; receptor abundance and recycling are therefore major control points in lipid homeostasis.
LDLR is a key target in cholesterol metabolism, lipoprotein trafficking, familial hypercholesterolaemia, atherosclerosis and cardiovascular research. Studies commonly examine receptor expression, endocytosis, recycling and regulation, including pathways that alter LDLR abundance, so researchers should match reagent species and application to the specific trafficking or expression question being tested.
Names used across publications, databases and supplier catalogues.
