ABMIUM target intelligence
bone morphogenetic protein receptor type 2
BMPR2 (bone morphogenetic protein receptor type 2; BMPR-II/BMPR-2) is a type II transmembrane serine/threonine kinase receptor in BMP signalling. In ligand-induced receptor complexes, BMPR2 activates type I BMP receptors, enabling downstream SMAD transcriptional responses.
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Research context & evidence
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BMPR2 is a type II receptor serine/threonine kinase that binds BMP-family ligands including BMP2 and BMP7. Upon ligand-dependent receptor-complex formation, BMPR2 phosphorylates and activates type I BMP receptors; activated type I receptors then engage SMAD transcriptional regulators. Curated UniProt evidence also supports non-canonical signalling through the p38 MAPK cascade in defined contexts.
BMPR2 is studied in BMP receptor signalling, vascular and developmental biology, receptor-complex assembly and canonical versus non-canonical pathway responses. Experimental work often examines how BMPR2 abundance, receptor partners and ligand context shape downstream SMAD or p38 MAPK signalling. Use the catalogue filters below to select ABMIUM reagents by species, application and product-level validation.
Names used across publications, databases and supplier catalogues.
