ABMIUM target intelligence
BCL2 binding component 3
BBC3 (BCL2 binding component 3), widely known as PUMA or p53 up-regulated modulator of apoptosis, is a pro-apoptotic BCL-2 family target studied in mitochondrial cell-death signalling. This catalogue-backed record links verified human BBC3 identity with Abmium research reagents.
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Names used across publications, databases and supplier catalogues.
BBC3/PUMA belongs to the BH3-only pro-apoptotic arm of the BCL-2 family. Pro-apoptotic BBC3 isoforms can engage anti-apoptotic BCL-2 family proteins and promote mitochondrial outer-membrane permeabilization, cytochrome c release and downstream caspase activation. Alternative splicing produces multiple isoforms, so isoform context should be considered when interpreting experimental data.
BBC3/PUMA is studied in intrinsic apoptosis, cellular stress responses and regulation of mitochondrial apoptotic commitment, including p53-responsive death signalling. Researchers commonly assess BBC3 expression or perturbation alongside other BCL-2-family regulators to understand survival-versus-death decisions. Confirm species, assay format, application and product-level validation for each Abmium reagent.