ABMIUM target intelligence
activating transcription factor 4
Activating transcription factor 4 (ATF4), also known as CREB-2 and cyclic AMP-dependent transcription factor ATF-4, is a bZIP transcription factor central to the integrated stress response. Human ATF4 maps to NCBI Gene 468 and reviewed UniProtKB P18848; this record links the verified target to related ABMIUM catalogue products.
Read full target overview![Anti-Human/Mouse/Rat ATF-4 Antibody [B792] - ABMIUM](http://www.abmium.com/cdn/shop/files/lEw5GfYJ.jpg?v=1781565889&width=520)
Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
ATF4 binds cAMP response elements and regulates metabolic and redox programmes while acting as a major transcriptional effector of the integrated stress response. Its translation rises during stresses including endoplasmic-reticulum stress, amino-acid starvation and oxidative stress, enabling adaptive stress-responsive gene expression.
ATF4 is studied in the integrated stress response, ER stress, amino-acid sensing, oxidative stress, metabolic/redox adaptation and stress-regulated transcription. Select related ABMIUM products only after confirming species, sample type, assay/application and product-level validation.
Names used across publications, databases and supplier catalogues.
