ABMIUM target intelligence
activating transcription factor 4
Activating transcription factor 4 (ATF4), also known as CREB-2 and cyclic AMP-dependent transcription factor ATF-4, is a bZIP transcription factor central to the integrated stress response. Human ATF4 maps to NCBI Gene 468 and reviewed UniProtKB P18848; this record links the verified target to related ABMIUM catalogue products.
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Research context & evidence
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ATF4 binds cAMP response elements and regulates metabolic and redox programmes while acting as a major transcriptional effector of the integrated stress response. Its translation rises during stresses including endoplasmic-reticulum stress, amino-acid starvation and oxidative stress, enabling adaptive stress-responsive gene expression.
ATF4 is studied in the integrated stress response, ER stress, amino-acid sensing, oxidative stress, metabolic/redox adaptation and stress-regulated transcription. Select related ABMIUM products only after confirming species, sample type, assay/application and product-level validation.
Names used across publications, databases and supplier catalogues.
