ABMIUM target intelligence
aldehyde dehydrogenase 3 family member A1
ALDH3A1 (aldehyde dehydrogenase 3 family member A1), also called the dimeric NADP-preferring aldehyde dehydrogenase, is a cytoplasmic enzyme that oxidises aromatic and medium-chain aldehydes. It is studied in aldehyde detoxification, lipid-peroxidation stress and corneal oxidative-protection biology.
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Research context & evidence
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ALDH3A1 forms a cytoplasmic homodimer and preferentially oxidises aromatic and medium-chain saturated or unsaturated aldehydes to corresponding acids. This activity contributes to reactive-carbonyl detoxification and has been linked to protection against UV- and 4-hydroxynonenal-associated oxidative damage in the cornea.
ALDH3A1 is investigated in cellular aldehyde clearance, lipid-peroxidation stress, corneal biology and resistance to reactive aldehydes. Measuring expression alongside enzyme activity can help resolve carbonyl-detoxification capacity across tissues and experimental stress conditions.
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