WP1066 (857064-38-1) is an inhibitor of the JAK2/STAT3 pathway as well as STAT5 and AKT. It downregulated Bcl-XL, Mcl-1, and c-myc while activating Bax and inducing apoptosis. Active against human malignant glioma U87-mg(IC50 = 5.6µM) and U373-mg(IC50 = 3.7µM) cells. Enhances T-cell cytotoxicity...
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WP1066 (857064-38-1) is an inhibitor of the JAK2/STAT3 pathway as well as STAT5 and AKT. It downregulated Bcl-XL, Mcl-1, and c-myc while activating Bax and inducing apoptosis. Active against human malignant glioma U87-mg(IC50 = 5.6µM) and U373-mg(IC50 = 3.7µM) cells. Enhances T-cell cytotoxicity via inhibition of regulatory T-cells. WP1066 abrogated PD-L1 expression in lymphoma cell lines
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