Selective inhibitor of the alanine-serine-cysteine transporter 2 (ASCT2 or SLC1A5; IC 50 = 9.0 µM rat and 9.6 µM human). It inhibited the uptake of both glutamine and possibly other amino acids in human cancer cells and reduced in vitro viability by at least 20% in more than half of 29 cancer...
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Selective inhibitor of the alanine-serine-cysteine transporter 2 (ASCT2 or SLC1A5; IC 50 = 9.0 µM rat and 9.6 µM human). It inhibited the uptake of both glutamine and possibly other amino acids in human cancer cells and reduced in vitro viability by at least 20% in more than half of 29 cancer cell lines screened. V-9302 decreased mTOR activity, elevated autophagy, and increased oxidative stress in multiple animal cancer models. Suppressed osteoclast differentiation in vitro and improved ovariectomy-induced bone loss in mice
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