Manufactured by:TriBio Science
RUO

V-9302, Glutamine transport inhibitor

Selective inhibitor of the alanine-serine-cysteine transporter 2 (ASCT2 or SLC1A5; IC 50 = 9.0 µM rat and 9.6 µM human). It inhibited the uptake of both glutamine and possibly other amino acids in human cancer cells and reduced in vitro viability by at least 20% in more than half of 29 cancer...

SKU:
ABM148918-1
Manufacturer SKU
TBI4245-25MG | TBI4245-5MG
Product type
Biochemical Inhibitors
TargetGlutamine transport
Purity>98%

Manufacturer provenance

Manufactured by:
TriBio Science
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

Selective inhibitor of the alanine-serine-cysteine transporter 2 (ASCT2 or SLC1A5; IC 50 = 9.0 µM rat and 9.6 µM human). It inhibited the uptake of both glutamine and possibly other amino acids in human cancer cells and reduced in vitro viability by at least 20% in more than half of 29 cancer cell lines screened. V-9302 decreased mTOR activity, elevated autophagy, and increased oxidative stress in multiple animal cancer models. Suppressed osteoclast differentiation in vitro and improved ovariectomy-induced bone loss in mice

Key facts & specifications
Also known as
(2S)-2-Amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid
Molecular weight
538.69
Form / buffer
powder
Activity
Selective inhibitor of the alanine-serine-cysteine transporter 2 (ASCT2 or SLC1A5; IC 50 = 9.0 µM rat and 9.6 µM human). It inhibited the uptake of both glutamine and possibly other amino acids in human cancer cells and reduced in vitro viability by at least 20% in more than half of 29 cancer cell lines screened. V-9302 decreased mTOR activity, elevated autophagy, and increased oxidative stress in multiple animal cancer models. Suppressed osteoclast differentiation in vitro and improved ovariectomy-induced bone loss in mice.
Molecular formula
C 34 H 38 N 2 O 4
Solubility
Soluble in DMSO (>70 mg/ml) or Ethanol (>30 mg/ml)
Technical note
Stability: ≥ 2 years.
Identifiers & database references
Manufacturer SKU
TBI4245-25MG | TBI4245-5MG
CAS number
1855871-76-9
Storage, stability & shipping
Storage conditions
-20°C
Shipped at
4°C
Long-term storage
-20°C
Compliance & documents
Datasheet
Open datasheet
Safety data sheet
Open SDS
Frequently asked questions
Who manufactured this product?

This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

TriBio Science
£368.00