Potent pan-JAK inhibitor, IC50s=1, 20 and 112 nM for JAK3, JAK2 and JAK1 respectively. Displays potent antiinflammatory and immunosuppressant activity. Promotes a white-to-brown metabolic conversion in human adipocytes. In therapeutic use for rheumatoid arthritis
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Potent pan-JAK inhibitor, IC50s=1, 20 and 112 nM for JAK3, JAK2 and JAK1 respectively. Displays potent antiinflammatory and immunosuppressant activity. Promotes a white-to-brown metabolic conversion in human adipocytes. In therapeutic use for rheumatoid arthritis
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