TOFA (54857-86-2) interferes with fatty acid synthase via inhibition of acetyl Co-A carboxylase (ACC1) IC 50 = 270 nM (for acetate incorporation). Induces apoptosis in a variety of tumor cell lines. Stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells. TOFA...
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TOFA (54857-86-2) interferes with fatty acid synthase via inhibition of acetyl Co-A carboxylase (ACC1) IC 50 = 270 nM (for acetate incorporation). Induces apoptosis in a variety of tumor cell lines. Stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells. TOFA impairs glucose-stimulated insulin secretion after chronic treatment. Suppresses the growth of ovarian cancer cells in vitro and in vivo
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